1) Install dependencies with MacPorts: sudo port install qt4-mac graphviz Get source code for qcachegrind: 2) Get kcachegrind-0.7.4.tar.gz from http://kcachegrind.sourceforge.net/html/Download.html 3) Unzip it: tar xfz ~/Downloads/kcachegrind-0.7.4.tar.gz We need "qmake" to find the right libraries 4) Set PATH to find the right "qmake": export PATH=/opt/local/libexec/qt4/bin:/opt/local/bin:/opt/local/sbin:$PATH 5) Set library path: export DYLD_LIBRARY_PATH=/opt/local/libexec/qt4/Library/Frameworks/ Compile: 6) Compile: cd kcachegrind-0.7.4/ cd qcachegrind/ qmake -nocache make mv qcachegrind.app /Applications/ Done! See also http://blogs.perl.org/users/rurban/2013/04/install-kachegrind-on-macosx-with-ports.html